Biomodels curates and annotates models for public use
As systems biologists develop models that attempt to simulate life, they need a good way to make them accessible to others as well as a good way to access other people’s models—and to...
Sep, 01, 2005
Competition inspires model improvements
During the summer of 2009, the International Neuroinformatics Coordinating Facility in Stockholm dangled a nearly $10,000 cash prize in front of neuron modelers and challenged them to do better. And...
Jan, 01, 2010
Confidence boost for modelers
It’s often said that all models are wrong, but some are useful. And one model that certainly falls in the “useful” category is the human lower-limb model that Scott Delp published...
Jun, 01, 2010
How researchers are combining disparate data types and simulating systems that contain many different moving parts
13 years ago Markus Covert, PhD, read a New York Times article that changed his life. The article quoted a prominent microbiologist who suggested that the ultimate test of one’s...
Feb, 16, 2013
The flu virus is an evolutionary marvel. Teams of experts design an appropriate flu vaccine annually just to keep up with the microbe’s ability to evade the human immune system. Multiple...
Jul, 01, 2006
A closer look at the curation of models discussed in The Physiome: A Mission Imperative
Multi-scale quantitative models need to be validated and reproducible if they are to be useful for clinical workflows, says Hunter. The Physiome infrastructure developed by Hunter, Dr Poul Nielsen...
Jun, 01, 2010
Navigating the oviduct and other mysteries
The essential elements of human fertilization are clear: sperm swim through the uterus, travel up the fallopian tube, and fertilize an egg. Not as well understood are the the nitty-gritty details of...
Jun, 19, 2013
How cell-centered models are adding fundamental insights into our understanding of cell behaviors
The cell is like our financial system: Even if you have a diagram of all the complex interactions going on, you still cannot intuit how the whole system will react when perturbed. Indeed, the cell...
Apr, 01, 2010
For a century, neuroscientists have dissected, traced, eavesdropped on, and are now compiling a seemingly endless cast of players in the nervous system. As we keep gathering more and more molecular...
Apr, 01, 2009
Computation offers a window into a disease often described as a black box
The growing threats of multi-drug resistant (MDR) and extensively drug resistant (XDR) tuberculosis (TB) are spurring worldwide interest in faster and more innovative research approaches, such as...
Jun, 06, 2012
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