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A Review of the Review

What this magazine has covered so far.

This, the sixth issue of this magazine (and the final issue of Volume 2), provides a good opportunity for reflection on where we’ve been and where we’re headed.  Three years ago, the...
Jul, 01, 2006
Computer Vision that Mimics Human Vision

Computer vision program rivals the human ability to rapidly recognize objects in a complex picture

Our brains can recognize most of the things we pass on an evening stroll: Cars, buildings, trees, and people all register even at a great distance or from an odd angle. Now, a new computer vision...
Jul, 01, 2007
New Technology Reveals the Genome’s 3D Shape

Hi-C technique looks at chromosomes at unprecedented level of resolution

Try taking a human hair as long as Manhattan and cramming it—unsnarled—inside a marble. This is the challenge faced by a 2-meter-long strand of DNA as it folds into its compact array of...
Jan, 01, 2010
Leveraging Social Media For Biomedical Research

How social media sites are rapidly doing unique research on large cohorts

It has become commonplace for people to use social media to share their healthcare stories, seek a community of individuals with the same diseases, and learn about treatment options. All this...
ALS, clinical trials, GWAS, Parkinsons, social media
Jan, 02, 2012
BIOSURVEILLANCE: From Text-mining to Freakidemiology

Researchers are expanding the types of data that can be used to predict infectious disease spread; developing novel ways to analyze that data; and trying to create systems that can help address public health problems today

American officials are seeking better ways to anticipate public health crises following ten years that have seen outbreaks of SARS, avian flu, H1N1, West Nile virus, cholera and, most recently,...
biosurveillance
Apr, 01, 2011
The Institute for Systems Biology

Pursuing the frontiers of systems biology in an interdisciplinary, non-academic enviroment

The Institute for Systems Biology (ISB) was founded in Seattle, Washington in 2000 by Leroy Hood, MD, PhD, Alan Aderem, PhD, and Reudi Aebersold, PhD. Five years later, they are pursuing the...
Apr, 01, 2006
Identifying and Overcoming Skepticism about Biomedical Computing

Modelers should take the lead.

Many collaborators 1        with whom modelers2 work have little or  no training in modeling3 and so it is natural that they may be cautious,...
Jun, 05, 2012
Sparks of Hope for a More Open Approach to Scientific Research and Publishing

Transparent peer review, replication studies, and journals of negative results all suggest change is on the horizon

As I was writing this editorial, I learned about yet another scientific paper being retracted. This time it was a genetics paper in Science, one of the hundreds of retractions that the blog...
errors, peer review, replication, scientific publication
Sep, 01, 2011
Error! – What Biomedical Computing Can Learn From Its Mistakes

How errors in data, software, and methodology can teach us how to do better

In 2006, a paper in Nature Medicine suggested a novel and potentially revolutionary method for predicting patient responses to cancer therapies using gene signatures. The finding piqued the interest...
publication, reproducible research, statistics, validation
Sep, 01, 2011
Simulated Buckyballs Bind to DNA

Still unknown:  Whether they can get inside cells

Recent research illustrates a nightmare scenario for nanotechnology: simulated particles called buckyballs eagerly glomming onto nearby DNA. The study, published in Biophysical Journal in December...
Apr, 01, 2006
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