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Modeling Whorls of Leaves

Computer simulation helps explain how plants grow

The petals of every flower and the leaves sprouting from every plant stalk have characteristic arrangements, a phenomenon called phyllotaxis. For two centuries, botanists have puzzled over the force...
Jul, 01, 2007
Zooming In on Blood Coagulation and Viscosity: Computation Takes On Blood Behavior

Simulations illuminate the inner workings of blood at multiple levels

Understanding blood flow and coagulation is crucial to treating blood disorders such as hemophilia and thrombosis, and to dealing with diseases such as AIDS, malaria, and diabetes that have...
Jun, 07, 2012
Watching Blood Vessels Grow and Shrink

2-D simulation shows angiogenesis as it happens

Microscopic capillaries grow on demand, snaking toward hungry cells needing their blood supply. Understanding how to control this process could help scientists promote wound healing or halt cancer in...
Jan, 01, 2007
Simulations Find Possible HIV Achilles’ Heel

Molecular dynamics simulations spot alternative drug target

A blindside attack on HIV-1 protease might just combat drug-resistant strains of HIV, according to simulations run by researchers at the University of California, San Diego. When the simulations shut...
Oct, 01, 2010
Bringing the Fruits of Computation to Bear on Human Health: It’s a Tough Job but the NIH Has to Do It
The National Institutes of Health are on a mission: To understand and tackle the problems of human health. To make that daunting problem approachable, 15 of the 20 institutes divvy up human health...
Oct, 05, 2012
SimVascular to Simulate Cardiovascular Flow
On the computer screen, vessels throb realistically with each pump of the heart while the river of blood swirls and pools at curves and intersections. This is a simulation built with SimVascular...
Apr, 01, 2007
Flowing through the Interactome
High-throughput experimental methods are widely used today to identify genes and proteins involved in a particular process, but not all molecules in a pathway can be identified in this manner. To...
Jul, 01, 2009
Genetic Variants and Ill Health: Scanning 500,000 SNPs Yields Gene-Disease Connections

It's an exhilarating time for genome-wide association studies

For the past few months it seemed you couldn’t open a journal without reading results of a new genome-wide association study. The results kept pouring in: four studies in April showing seven...
Oct, 01, 2007
Aquaporin Simulations De-Bunk Gas Exchange Assumptions
Biologists have long taken gas exchange for granted, assuming that gases simply seep through the cell’s lipid membrane. Since 1998, however, evidence has been building that gases might also be...
Jul, 01, 2007
Hot Bodies a Lure for Unseen Specks

Computing airflow dynamics

We can’t see them, but tiny particles—dust, pollen, microbes, and the like—swirl around us in complicated, turbulent pathways. New numerical simulations suggest that, at least in...
Jun, 01, 2010
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