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The Golden Age of Public Databases: Speeding Biomedical Discovery

Public databases impact not only how research is done but what kind of research is done in the first place.

The setting: a scientific conference in January 2008. The speaker, Bruce Ponder, MD, PhD, an oncology professor at Cambridge University, is describing a previously unknown link between a particular...
Oct, 01, 2008
Imaging Collections: How They're Stacking Up

As barriers to massive imaging collections fall, researchers can look at human systems in their entirety rather than in pieces

In the beginning there was the Visible Human. It broke new ground by gathering some 2,000 serial images from a death row inmate’s cadaver, and was the first time researchers had sectioned a...
Jul, 01, 2007
Genetic Variants and Ill Health: Scanning 500,000 SNPs Yields Gene-Disease Connections

It's an exhilarating time for genome-wide association studies

For the past few months it seemed you couldn’t open a journal without reading results of a new genome-wide association study. The results kept pouring in: four studies in April showing seven...
Oct, 01, 2007
Privacy and Biomedical Research: Building a Trust Infrastructure

An exploration of data-driven and process-driven approaches to data privacy

Trust. It’s the basis of every patient/physician interaction: Shared personal health information is kept confidential and used only for the patient’s benefit. It’s a tradition that...
de-identification, differential privacy, HIPAA, k-anonymity, l-anonymity, privacy
Jan, 02, 2012
Share and Share Alike: A Proposed Set of Guidelines for Both Data and Software
A pair of challenges increasingly threaten the success of bioinformatics research: convincing biologists to share their data and convincing computational colleagues to share their code. Many of us...
Jul, 01, 2006
The BiGG Picture

A virtual metabolic network represents intracellular traffic

It’s hard to imagine a map depicting the daily flow of traffic on water, wheels and foot throughout San Diego—or any large city—over the course of a day. “That map can...
Apr, 01, 2007
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Feb, 22, 2012
Automating Scientific Discovery

A robot that develops hypotheses of its own

Robots already have a place in many labs, automating tedious tasks such as pipetting samples. But a new system designed at Aberystwyth University in the United Kingdom has taken laboratory automation...
Jul, 01, 2009
Computing Has Changed Biology Forever

And people are starting to notice

In 1991, a prescient editorial in Nature by Harvard’s Walter Gilbert, PhD, (“Towards a paradigm shift in biology”) included these observations on the utility and impact of computing...
Apr, 01, 2006
Molecular Biology Wikis Launched

Central repository of information on genes and proteins requires participation by the scientific community

If you build it, will they come? That’s the question on everyone’s mind after the launch of two pioneering initiatives in community annotation: WikiProteins and Gene Wiki, announced,...
Oct, 01, 2008
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