An exploration of data-driven and process-driven approaches to data privacy
Trust. It’s the basis of every patient/physician interaction: Shared personal health information is kept confidential and used only for the patient’s benefit. It’s a tradition that...
Jan, 02, 2012
Many a successful investigator working at the interface between molecular biology, genetics and computation will recognize the imperative to obtain biological validation for computational...
Jul, 01, 2008
High-throughput experimental methods are widely used today to identify genes and proteins involved in a particular process, but not all molecules in a pathway can be identified in this manner. To...
Jul, 01, 2009
Incremental progress and measured successes
Personalized cancer therapy is now a reality. A handful of tumor-classifying tests and targeted drugs are in widespread clinical use; and early attempts are underway to match high-risk cancer...
Jan, 02, 2012
Computation shows that the skull guides the wrinkling
In the four months before birth, a fetus’s brain grows from a smooth tube of neurons into a highly crinkled, convolved mass of tissue. Because the cerebral cortex has a surface area nearly...
Jun, 01, 2010
Imaging, geometric modeling, representation and computing of shapes and forms are important components of modern computational biology. These processes apply across wide spectra of scales,...
Oct, 03, 2012
How researchers are combining disparate data types and simulating systems that contain many different moving parts
13 years ago Markus Covert, PhD, read a New York Times article that changed his life. The article quoted a prominent microbiologist who suggested that the ultimate test of one’s...
Feb, 16, 2013
How mathematical models are transforming the fight against cancer
The most common test for prostate cancer (known as PSA screening) misses aggressively growing prostate tumors—the type typically seen in young patients. It’s a fact that was accepted by...
Apr, 01, 2007
A new simulation mimics the virus’s infection cycle on the tonsils, shedding some light on how the infection spreads
During our lives, most of us will come in contact with the Epstein-Barr virus, commonly known as that bane of teenagers, infectious mononucleosis. Now, a new simulation mimics the virus’s...
Jan, 01, 2008
There is growing recognition that epigenetics may be just as important as genetics in human health and disease.
In the early 19th century, Jean-Baptiste Lamarck explained evolution as the inheritance of acquired traits; he believed that changes due to behaviors and exposures in one generation could be passed...
Jun, 01, 2010
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