Researchers are expanding the types of data that can be used to predict infectious disease spread; developing novel ways to analyze that data; and trying to create systems that can help address public health problems today
American officials are seeking better ways to anticipate public health crises following ten years that have seen outbreaks of SARS, avian flu, H1N1, West Nile virus, cholera and, most recently,...
Apr, 01, 2011
It's an exhilarating time for genome-wide association studies
For the past few months it seemed you couldn’t open a journal without reading results of a new genome-wide association study. The results kept pouring in: four studies in April showing seven...
Oct, 01, 2007
The Human Genome Project has spurred extraordinary developments in our ability to characterize cellular systems in high-throughput fashion. Polymorphism, methylation, gene expression, and proteomics...
Apr, 01, 2008
Ontologies provide biomedical researchers with an inventory of the universal features of reality across organisms, biomedical disciplines, and levels of granularity. In capturing what is universal,...
Jul, 01, 2009
New approaches extend multiscale models to represent cellular mesoscales and bridge from molecular to cellular models
In an era of increasingly comprehensive molecular characterizations of living systems, computation has emerged as a key technology to facilitate integrative understanding of biological mechanisms....
Feb, 19, 2013
Diabetes, breast cancer, multiple sclerosis, Alzheimer’s disease. All are associated with several genes’ alleles interacting in complex ways with one another and the environment. Now,...
Jul, 01, 2007
There is growing recognition that epigenetics may be just as important as genetics in human health and disease.
In the early 19th century, Jean-Baptiste Lamarck explained evolution as the inheritance of acquired traits; he believed that changes due to behaviors and exposures in one generation could be passed...
Jun, 01, 2010
A recognition of biocomputing's successes and a prediction of what's to come
The last ten years have seen huge leaps in biomedical computing. We now have new ways to integrate and understand vast quantities of data; the capacity for multi-scale biological modeling; and a...
bioinformatics tools, biomedical computing, CAD, computational modeling, data mining, disease surveillance, dynamic modeling, education, eric jakobsson, function prediction, genetic association, genome annotation, in silico screening, medical informatics, neuromodeling, prosthetics, sequence alignment, structure prediction, systems biology, systems biomedicine, telemedicine, tomography
Jun, 01, 2005
The study of HIV evolution is not only critical to fighting the virus; it has also driven advances in the computational tools used to study evolution in general.
When Darwin published On the Origin of Species in 1859, it would be decades before HIV would jump from monkeys to humans and set off a devastating worldwide pandemic. But evolution is at the heart of...
Jul, 01, 2009
Connectivity Map helps connect drugs and diseases
Normal cells, diseased cells and cells on drugs share a common language: They all produce their own patterns of gene expression. And the patterns can be compared in useful ways—given a disease...
Jan, 01, 2007
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