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Successful Collaborations: Helping biomedicine and computation play well together

Collaborations are a fact of life for interdisciplinary fields like biomedical computing, and social scientists can help researchers understand how to make them more productive

Social scientists who study science have noticed a trend: More and more researchers are collaborating. Over the last twenty years, the number of co-authored papers has increased in every scientific...
Jul, 01, 2008
Feedback for the Brain and Body: A New Freely Available Interface Between MATLAB and OpenSim
Even when we simply stand still on two feet, our brains communicate with our muscles—firing them appropriately to keep us upright against gravity. So when scientists simulate simple or complex...
Jun, 06, 2012
Dock This: In Silico Drug Design Feeds Drug Development

As algorithms evolve, computing power explodes, and scientists solve a greater number of 3-D protein structures, computer-aided design has the potential to dramatically cut the cost and time of drug discovery

Once upon a time, not long ago, HIV/AIDS was a scourge, killing anyone who contracted the deadly virus. Now, many people are living with the disease, which they control with drugs initially developed...
Jul, 01, 2007
Janelia Farm: Cultivating Scientists

Janelia farmers pursue novel, cross-disciplinary collaborations to work on long-term, unwieldy scientific problems difficult to tackle in a single laboratory

The folks at Howard Hughes Medical Institute who dreamed up Janelia Farm say it is as much a social innovation as a scientific one. “We are creating a different culture here,” says Gerald...
Jul, 01, 2006
From SNPs to Prescriptions: Can Genes Predict Drug Response?

Decades of steady progress in pharmacogenetics have unearthed hundreds of associations between genes and drug response. But the field has to solve some theoretical and practical issues before it can deliver on the promise of personalized drug therapy.

As algorithms go, it’s deceptively simple. Just add together eight weighted pieces of patient information—age, height, weight, race, data about two genes, and a pair of clinical...
Jul, 01, 2009
Imaging Collections: How They're Stacking Up

As barriers to massive imaging collections fall, researchers can look at human systems in their entirety rather than in pieces

In the beginning there was the Visible Human. It broke new ground by gathering some 2,000 serial images from a death row inmate’s cadaver, and was the first time researchers had sectioned a...
Jul, 01, 2007
Cells' Collaborative Middle Management

Describing information flow within cells

Like corporate and governmental organizations, cells rely on middle managers to keep things running smoothly. These “middle managers” function as a critical bridge that controls the flow...
Jun, 01, 2010
BENCH-SIDE COMPUTATION: New Tools to Accelerate Experimental Research

It’s impossible to predict what the hottest new tools will be, but here are a few gems that caught our attention

Many experimental researchers rely on computational tools to push the pace and productivity of laboratory research. It’s impossible to predict what the hottest new tools will be, but this...
protein dynamics, simulation, visual system
Apr, 01, 2011
The Institute for Systems Biology

Pursuing the frontiers of systems biology in an interdisciplinary, non-academic enviroment

The Institute for Systems Biology (ISB) was founded in Seattle, Washington in 2000 by Leroy Hood, MD, PhD, Alan Aderem, PhD, and Reudi Aebersold, PhD. Five years later, they are pursuing the...
Apr, 01, 2006
Santa Fe Institute: Addressing Complexity

A safe haven for asking fundamental, wide-ranging questions

In the summer, it can be hard to find a place to sit at the Santa Fe Institute. Much of the year, only about a dozen researchers make their home at the multidisciplinary research organization. But in...
Oct, 01, 2006
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