Mechanical forces drive many processes in the human body, from organ and tissue formation during development, to stem cell differentiation, to wound healing. Until recently, scientists could only...
Oct, 01, 2009
In science, there is a need to balance research in domain sciences and the infrastructure to support that research. Basic research mediated through peer review is understood to produce useful...
Jan, 01, 2007
Assuring accuracy and efficiency
In simulations of human activities such as running, hundreds of individual musculotendon models turn on and off to swing the arms and legs. Naturally, these simulations can only be as accurate and...
Jun, 19, 2013
There are numerous musculoskeletal modeling methods available to make predictions of muscle and joint contact forces. While such predictions can help improve treatments for movement-related disorders...
Jan, 02, 2012
Balancing Breadth and Depth
The last decade saw a proliferation of training programs at the intersection of life science and computation, with more than 60 new degree and certificate programs launched in the United States alone...
Sep, 01, 2005
Knot-detecting algorithm discovers that proteins are rarely knotted
When you accidentally twist a shoelace, garden hose, or necklace, it can get annoyingly tangled into intractable knots. On the microscopic level, biopolymers—string-like molecules such as DNA...
Oct, 01, 2010
AMOEBA's polarizable force field now integrated with OpenMM
Many have long hoped that molecular dynamics calculations—the computation of how molecules move and interact with other molecules—would revolutionize the world of synthetic chemistry,...
Sep, 01, 2011
Computational simulations of life in motion at every scale—molecular, cellular, tissue-level, and whole organism—are boosting our understanding of the role mechanics plays in controlling life.
From atoms and molecules to insects, dinosaurs, and humans, computational researchers are finding that much of life can be understood in mechanical terms. Indeed, the machines of life are...
Jan, 01, 2008
Either/or molecular circuitry modeled
To differentiate or not to differentiate? That is the question constantly faced by embryonic stem cells. And they seem to answer it decisively at the behest of a molecular trio of transcription...
Jan, 01, 2007
A closer look at the curation of models discussed in The Physiome: A Mission Imperative
Multi-scale quantitative models need to be validated and reproducible if they are to be useful for clinical workflows, says Hunter. The Physiome infrastructure developed by Hunter, Dr Poul Nielsen...
Jun, 01, 2010
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