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Calculating Statistics of Arm Movements

An explanation of geometric constraints in computational biomechanics

  Suppose 20 friends live in the same city and want to meet for dinner. They should be able to identify a unique spot that minimizes the squared distance everyone needs to travel by taking the...
geometric constraints
Jan, 02, 2012
Behind the Connectome Commotion

Exploring the current state of connectomics--in the midst of hype

Connectomics is having a moment. Following on the heels of genomics, proteomics, transcriptomics, metabolomics, and microbiomics, the latest “omic” to seize the spotlight is generating...
brain, connectome
Jun, 20, 2013
New Technology Reveals the Genome’s 3D Shape

Hi-C technique looks at chromosomes at unprecedented level of resolution

Try taking a human hair as long as Manhattan and cramming it—unsnarled—inside a marble. This is the challenge faced by a 2-meter-long strand of DNA as it folds into its compact array of...
Jan, 01, 2010
Studying Force in 3-D
Mechanical forces drive many processes in the human body, from organ and tissue formation during development, to stem cell differentiation, to wound healing. Until recently, scientists could only...
Oct, 01, 2009
Packing It All In: Curricula for Biomedical Computing

Balancing Breadth and Depth

The last decade saw a proliferation of training programs at the intersection of life science and computation, with more than 60 new degree and certificate programs launched in the United States alone...
Sep, 01, 2005
Computing Better Enzymes: Optimizing Directed Evolution

Using computation, researchers narrow the search space for directed evolution; guide mutagenesis; and create de novo enzymes

Enzymes are among nature’s crowning achievements: they accelerate chemical reactions, making life possible. People have co-opted natural enzymes for industrial use for thousands of years (think...
Feb, 19, 2013
Brain Folding

Computation shows that the skull guides the wrinkling

In the four months before birth, a fetus’s brain grows from a smooth tube of neurons into a highly crinkled, convolved mass of tissue. Because the cerebral cortex has a surface area nearly...
Jun, 01, 2010
Making DNA Smile

Researcher coaxes long strands of DNA into predetermined geometric shapes

Designing nanostructures of DNA just got easier. Paul Rothemund, PhD, a senior research fellow at Caltech has found a way to coax a long strand of DNA into a predetermined geometric shape by mixing...
Jul, 01, 2006
SimVascular to Simulate Cardiovascular Flow
On the computer screen, vessels throb realistically with each pump of the heart while the river of blood swirls and pools at curves and intersections. This is a simulation built with SimVascular...
Apr, 01, 2007
SimVascular User Profile: Alison Marsden, PhD

University of California, San Diego’s Alison Marsden uses SimVascular to do patient-specific modeling of blood flow for surgical applications.

from http://biomedicalcomputationreview.org/content/simbios-bringing-biomedical-simulation-your-fingertips   Alison Marsden, PhD, an assistant professor of mechanical and aerospace engineering...
Oct, 01, 2009
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