In a classic cartoon, a physician offers a second opinion from his computer. The patient looks horrified: How absurd to think that a computer could have better judgment than a human doctor! But...
Jan, 01, 2010
Can the complexities of biology be boiled down to Amazon.com-style recommendations? The examples here suggest possible pathways to an intelligent healthcare system with big data at its core.
“We have recommendations for you,” announces the website Amazon.com each time a customer signs in.
This mega-retailer analyzes billions of customers’ purchases—nearly $...
Jan, 02, 2012
Refining the practical applications of the science in Personalized Cancer Treatment: Seeking Cures Through Computation
Gene expression signatures that stratify patients into likely and...
Jan, 02, 2012
Computationally modeling the hot spots
Tiny gold particles that absorb laser light and convert it into heat are a promising therapy for destroying tumors. However, controlling the temperature of such gold nanoshells is crucial: The shells...
Jan, 01, 2010
No two cancer patients respond identically to treatment. Some will be cured while others will see their cancer return, and physicians are at a loss to explain why. Now, using MRI imaging researchers...
Oct, 01, 2009
The Virtual Physiological Human (VPH) would encompass all the knowledge we’ve gathered, from genetic interactions to systems biology, into one integrated digital package
Science and medicine have fractured the human body into pieces: the cardiovascular system, the immune system, the endocrine system. Now a European initiative seeks to put the jigsaw puzzle back...
Jan, 01, 2008
Researchers developing a new vaccine currently have no direct way of predicting its efficacy short of exposing patients to the disease. A new study that combines gene expression data with advanced...
Apr, 01, 2009
Models of healthy and diseased lipid profiles could prove valuable diagnostically.
When it comes to heart disease risk, “bad” and “good” cholesterol—also known as low density lipoproteins [LDL] and high density lipoproteins [HDL]—do not tell...
Oct, 01, 2008
Using a 3-D computer model, scientists have simulated stem cells growing within a scaffold to predict which combination of properties will produce the most bone
Designing a scaffold, the internal structure that helps patients regenerate bone, is a delicate balancing act. The scaffold must be strong enough to protect the injury, porous enough to allow...
Jan, 01, 2008
The importance of developing and deploying tools for the quantitative clinician scientist
The word Om (or Aum) has many meanings in ancient Hindu philosophy, one of which is “that which contains all other sounds.” The meaning has relevance to the now commonly used suffix...
Jun, 01, 2010
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