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Untangling Integrative Analysis

How researchers are combining disparate data types and simulating systems that contain many different moving parts

13 years ago Markus Covert, PhD, read a New York Times article that changed his life.  The article quoted a prominent microbiologist who suggested that the ultimate test of one’s...
Feb, 16, 2013
Integrative Cancer Biology Program is Born
The National Cancer Institute launched the Integrative Cancer Biology Program (ICBP) in October 2004, providing a total of $15 million to nine multidisciplinary centers. The goal: to use predictive...
cancer, integrative
Jun, 01, 2005
Democratizing Integrative Biology

The importance of developing and deploying tools for the quantitative clinician scientist

The word Om (or Aum) has many meanings in ancient Hindu philosophy, one of which is “that which contains all other sounds.” The meaning has relevance to the now commonly used suffix...
Jun, 01, 2010
2012 Update on the National Centers for Biomedical Computing

The Principal Investigators weigh in

Ever since the National Institutes of Health (NIH) began funding the National Centers for Biomedical Computing (NCBCs) just over seven years ago, these powerhouses have been plugging away, building...
NCBC
Feb, 29, 2012
Three New Centers
The National Institutes of Health Roadmap for Medical Research has recently completed the first stage of an ambitious program to expand the computational infrastructure and software tools needed to...
Jan, 01, 2006
Multiscale Modeling in Biomedical Research

New approaches extend multiscale models to represent cellular mesoscales and bridge from molecular to cellular models

In an era of increasingly comprehensive molecular characterizations of living systems, computation has emerged as a key technology to facilitate integrative understanding of biological mechanisms....
Feb, 19, 2013
A Digital Human Could Advance Medicine

The Virtual Physiological Human (VPH) would encompass all the knowledge we’ve gathered, from genetic interactions to systems biology, into one integrated digital package

Science and medicine have fractured the human body into pieces: the cardiovascular system, the immune system, the endocrine system. Now a European initiative seeks to put the jigsaw puzzle back...
Jan, 01, 2008
Modeling Cancer Biology: Reaching beyond human intuition and linear thinking

How mathematical models are transforming the fight against cancer

The most common test for prostate cancer (known as PSA screening) misses aggressively growing prostate tumors—the type typically seen in young patients. It’s a fact that was accepted by...
Apr, 01, 2007
Bringing the Fruits of Computation to Bear on Human Health: It’s a Tough Job but the NIH Has to Do It
The National Institutes of Health are on a mission: To understand and tackle the problems of human health. To make that daunting problem approachable, 15 of the 20 institutes divvy up human health...
Oct, 05, 2012
NCBCs Take Stock and Look Forward: Fruitful Centers Face Sunset

From hardened software to scientific productivity, the NCBCs have changed the landscape for biomedical computing.  What will happen when their funding expires?

It has been eight years since the National Institutes of Health (NIH) funded the first National Centers for Biomedical Computing (NCBCs). With two or three years remaining in the program (...
ccb, i2b2, Magnet, na-mic, ncbo, NCIBI, Simbios
Oct, 19, 2012
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