Biomodels curates and annotates models for public use
As systems biologists develop models that attempt to simulate life, they need a good way to make them accessible to others as well as a good way to access other people’s models—and to...
Sep, 01, 2005
Assuring accuracy and efficiency
In simulations of human activities such as running, hundreds of individual musculotendon models turn on and off to swing the arms and legs. Naturally, these simulations can only be as accurate and...
Jun, 19, 2013
Confidence boost for modelers
It’s often said that all models are wrong, but some are useful. And one model that certainly falls in the “useful” category is the human lower-limb model that Scott Delp published...
Jun, 01, 2010
Competition inspires model improvements
During the summer of 2009, the International Neuroinformatics Coordinating Facility in Stockholm dangled a nearly $10,000 cash prize in front of neuron modelers and challenged them to do better. And...
Jan, 01, 2010
How researchers are combining disparate data types and simulating systems that contain many different moving parts
13 years ago Markus Covert, PhD, read a New York Times article that changed his life. The article quoted a prominent microbiologist who suggested that the ultimate test of one’s...
Feb, 16, 2013
The flu virus is an evolutionary marvel. Teams of experts design an appropriate flu vaccine annually just to keep up with the microbe’s ability to evade the human immune system. Multiple...
Jul, 01, 2006
A physically-based facial muscle model for animation
He speaks: “Algorithm.” And you can just about read his lips.
The movie was created using muscle-driven physics-based animation. Other techniques might produce images that look...
Oct, 01, 2007
A closer look at the curation of models discussed in The Physiome: A Mission Imperative
Multi-scale quantitative models need to be validated and reproducible if they are to be useful for clinical workflows, says Hunter. The Physiome infrastructure developed by Hunter, Dr Poul Nielsen...
Jun, 01, 2010
Decades of steady progress in pharmacogenetics have unearthed hundreds of associations between genes and drug response. But the field has to solve some theoretical and practical issues before it can deliver on the promise of personalized drug therapy.
As algorithms go, it’s deceptively simple. Just add together eight weighted pieces of patient information—age, height, weight, race, data about two genes, and a pair of clinical...
Jul, 01, 2009
For a century, neuroscientists have dissected, traced, eavesdropped on, and are now compiling a seemingly endless cast of players in the nervous system. As we keep gathering more and more molecular...
Apr, 01, 2009
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