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Update on Biomedical Computation at NIH

Helping newcomers understand the lay of the land

As a program manager in biomedical computing and computational biology at the National Institutes of Health, I field many questions, particularly from new investigators. They ask questions like:...
Apr, 01, 2010
Teaching Biology and Physics Together
While science educators actively debate the relative merits of teaching natural science in an integrated fashion, some authors are writing texts that will make it happen. Philip Nelson’s book,...
Jun, 01, 2005
Bridging the Scientific Divide: Enabling Sharing through Biomedical Computing

How to share knowledge, data, tools, and computational resources in a sustainable manner

Once upon a time, a deep divide existed between scientists who did and those who did not have easy access to scientific content (journals, lectures, data), hardware (imaging devices, lab instruments...
sharing
Apr, 01, 2011
Sparks of Hope for a More Open Approach to Scientific Research and Publishing

Transparent peer review, replication studies, and journals of negative results all suggest change is on the horizon

As I was writing this editorial, I learned about yet another scientific paper being retracted. This time it was a genetics paper in Science, one of the hundreds of retractions that the blog...
errors, peer review, replication, scientific publication
Sep, 01, 2011
Editor's Picks Fall 2005

Open Source reflections; designing with code re-use; and Cygwin

Do you have a few favorite books that you recommend to anyone with an interest in biomedical computing? Are there software products or Web sites that you love to evangelize? We’d like to open...
Sep, 01, 2005
Error! – What Biomedical Computing Can Learn From Its Mistakes

How errors in data, software, and methodology can teach us how to do better

In 2006, a paper in Nature Medicine suggested a novel and potentially revolutionary method for predicting patient responses to cancer therapies using gene signatures. The finding piqued the interest...
publication, reproducible research, statistics, validation
Sep, 01, 2011
Human Versus Machine: Biomedical expertise meets computer automation

Computers and human experts duke it out over who is better at diagnosing disease, interpreting images, or predicting protein structure

Dorothy Rosenthal tenses over her microscope, peering at the problematic nucleus on the Pap smear yet again. “It’s abnormal,” she decides, and then hesitates. “No, it’s...
Jul, 01, 2006
Modeling the Deformable Body
August 2007 saw a surge of new open-source software for simulating musculoskeletal movement. In addition to OpenSim 1.0 (described in the Fall 2007 issue of this magazine), FEBio arrived on the scene...
Apr, 01, 2008
Recognizing and Encouraging Timely Dissemination
The availability of free and open access data, models, and software indisputably accelerates scientific progress. Unfortunately, dissemination necessitates organization, documentation, and quality...
Jan, 01, 2010
Putting Heads Together

Upcoming biocomputing conferences

The 6th Annual International Conference on Computational Systems Bioinformatics (CSB2007) coordinated by the Life Sciences Society. WHAT: This conference is designed for any scientist interested in...
Jul, 01, 2007
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