Molecular dynamics simulations spot alternative drug target
A blindside attack on HIV-1 protease might just combat drug-resistant strains of HIV, according to simulations run by researchers at the University of California, San Diego. When the simulations shut...
Oct, 01, 2010
Disentangling the different types of skeptics and what modelers can learn from each.
What are the telltale signs of a modeling talk at a biology conference? Just look for the sighs, shifting, and eye-rolling in the audience, says Donald C. Bolser, PhD, professor of physiological...
Jun, 05, 2012
How Simbios' state-of-the-art software tools are contributing to high-impact biomedical research
Simbios began with a simple idea: that physics-based simulation of biological structures at all scales could benefit from a
unified tool-building effort.
At the same time, the thinking went,...
Oct, 01, 2009
Computing using time steps -- a necessary approximation
Time flows like a continuous, steady river. And it moves forward—never back. These facts create inherent challenges for computer simulations of biological molecules in motion.
It would...
Jun, 19, 2013
Simulation of a one-million-atom virus reveals unexpected twist
Giving new meaning to the phrase computer virus, researchers have created a computer simulation of an entire biological virus comprising approximately one million atoms.
“It wasn’t...
Jul, 01, 2006
Biologists have long taken gas exchange for granted, assuming that gases simply seep through the cell’s lipid membrane. Since 1998, however, evidence has been building that gases might also be...
Jul, 01, 2007
The Principal Investigators weigh in
Ever since the National Institutes of Health (NIH) began funding the National Centers for Biomedical Computing (NCBCs) just over seven years ago, these powerhouses have been plugging away, building...
Feb, 29, 2012
Computational simulations of life in motion at every scale—molecular, cellular, tissue-level, and whole organism—are boosting our understanding of the role mechanics plays in controlling life.
From atoms and molecules to insects, dinosaurs, and humans, computational researchers are finding that much of life can be understood in mechanical terms. Indeed, the machines of life are...
Jan, 01, 2008
Researchers can now create musculoskeletal models and simulations on an open source platform. In August, Simbios researchers released OpenSim 1.0. This freely available software can, in about 20...
Oct, 01, 2007
New release improves both GUI and API
OpenSim, the neuromuscular modeling and simulation software, is now available in a new digit: 3.0. The change (up from 2.4) reflects significant improvements that make this open source tool more...
Oct, 19, 2012
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