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Research Reproducibility from MSWord

Making reproducible research accessible to people who don’t write code

A particular mashup of data and tools produces the unique results found in each computational biology publication. Now, researchers have developed a model system that gives readers—especially...
Apr, 01, 2010
Privacy and Biomedical Research: Building a Trust Infrastructure

An exploration of data-driven and process-driven approaches to data privacy

Trust. It’s the basis of every patient/physician interaction: Shared personal health information is kept confidential and used only for the patient’s benefit. It’s a tradition that...
de-identification, differential privacy, HIPAA, k-anonymity, l-anonymity, privacy
Jan, 02, 2012
Sensational Sequences

A new media artwork explores novel ways to represent and intuitively understand nature in the metagenomic era

What’s it like to be immersed in a dataset of millions of DNA sequences? Audiences of ATLAS in silico—a new media artwork that explores novel ways to represent and intuitively understand...
Oct, 01, 2008
Journey to the NIH: Insights and Inspirations from the 2012 NCBC Showcase

Postdocs get a glance at the entire field and their first inside view of NIH grant-making

If he were a graduate student now, Francis Collins would be studying computational biology. That’s what the Director of the National Institutes of Health (NIH) told a rapt audience at the...
Feb, 19, 2013
Profiles in Computer Science Courage Part I: Reflections on the rewards of plunging into biomedicine

Interviews with Leonidas Guibas, Ron Shamir, Michael Black, David Haussler, Daphne Koller, Erin Halperin, Gene Myers, Paul Groth and Bruce Donald

To a computer scientist, the fields of biology and medicine can seem like the vast Pacific Ocean, says Leonidas Guibas, PhD, professor of computer science at Stanford University. “You go to the...
Careers, computer science
Apr, 01, 2011
Breathing Life Into Paper
The edict that academics must “publish or perish” serves not merely to advance careers, but also to stress the importance of transmitting knowledge from scientist to scientist and...
Jan, 01, 2006
Getting It Right: Better Validation Key to Progress in Biomedical Computing

Bringing models closer to reality

When the ill-fated space shuttle Columbia launched on January 16, 2003, a large piece of foam fell off and hit the left wing. Alerted of the impact, NASA engineers used a computer model to predict...
7009, competitions, outsource, self-assessment, validation
Oct, 19, 2012
Error! – What Biomedical Computing Can Learn From Its Mistakes

How errors in data, software, and methodology can teach us how to do better

In 2006, a paper in Nature Medicine suggested a novel and potentially revolutionary method for predicting patient responses to cancer therapies using gene signatures. The finding piqued the interest...
publication, reproducible research, statistics, validation
Sep, 01, 2011
The Golden Age of Public Databases: Speeding Biomedical Discovery

Public databases impact not only how research is done but what kind of research is done in the first place.

The setting: a scientific conference in January 2008. The speaker, Bruce Ponder, MD, PhD, an oncology professor at Cambridge University, is describing a previously unknown link between a particular...
Oct, 01, 2008
The Physiome: Standardizing the Physiome

A closer look at the curation of models discussed in The Physiome: A Mission Imperative

Multi-scale quantitative models need to be validated and reproducible if they are to be useful for clinical workflows, says Hunter. The Physiome infrastructure developed by Hunter, Dr Poul Nielsen...
Jun, 01, 2010
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