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Reverse-Engineering Transcriptional Networks

Finding the Master Regulators

A cell may change states several times in its lifetime—from a stem cell to a specialized cell, for example, or from a normal cell to a cancerous one. Each time this happens, a veritable army of...
Apr, 01, 2010
Reverse Engineering the Brain
For a century, neuroscientists have dissected, traced, eavesdropped on, and are now compiling a seemingly endless cast of players in the nervous system. As we keep gathering more and more molecular...
neuron, reverse engineer
Apr, 01, 2009
Flexible Molecular Computer Functions Inside a Cell
A newly created molecular computer works in human cells and offers the flexibility of a general-purpose circuit. The advance, described in Nature Biotechnology in May, brings closer the eventual...
Oct, 01, 2007
Ramping Up to Multiscale: Taking Biomedical Modeling to a New Level

Multi-scale modeling is now at what might be called its gestational stage

For centuries, mathematics has been an indispensable ally of the physical sciences and engineering. Planes fly and telephones work because engineers know how to simplify physical systems into...
Apr, 01, 2006
Chromatin Fiber: Zigzag or Solenoid?
Try packing a two-meter-long stretch of DNA into a cell nucleus just a few millionths of a meter thick—with key coding segments readily accessible. It’s a seemingly impossible feat that...
Oct, 01, 2009
Editor's Picks
One of our goals at Biomedical Computation Review is to create a sense of kinship among members of this very diverse community of researchers. This column provides reviews of some of the latest and...
Jun, 01, 2005
MEART: The Semi-Living Artist

Cultured brain cells draw pictures

MEART’s creators link the basic components of the brain (isolated neurons) to a mechanical body (robotic arms) through the mediation of a digital processing engine across the Internet. The goal...
Oct, 01, 2010
Moon Shots in Biomedical Computation

As leaders and participants of an effort to build an infrastructure that enables biomedical computing on a broad basis, it is incumbent upon us to define clear and challenging goals that will dazzle the world

The world changed when Neil Armstrong set foot on the moon in 1969. Humans could survive outside the earth’s atmosphere! Science and engineering could achieve great things! And the nerds at the...
Jan, 01, 2008
A Model Neuron
For patients suffering from nerve damage, neural regeneration is a faint hope. It rarely happens naturally, and attempts to coax new growth often fail. Researchers are trying to develop scaffolds to...
Apr, 01, 2009
On Your Mark, Get Set, Build Infrastructure: The NCBC Launch

The first four National Centers for Biomedical Computing take off

WHY NATIONAL CENTERS? Four National Centers for Biomedical Computing were launched by the NIH in 2004 with $20 million in funding for each center over five years. The reason: We need to make...
Jun, 01, 2005
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