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Getting It Right: Better Validation Key to Progress in Biomedical Computing

Bringing models closer to reality

When the ill-fated space shuttle Columbia launched on January 16, 2003, a large piece of foam fell off and hit the left wing. Alerted of the impact, NASA engineers used a computer model to predict...
7009, competitions, outsource, self-assessment, validation
Oct, 19, 2012
Profiles in Computer Science Courage Part II: Advice on Taking the Plunge
Words of Advice from the Scientists Featured in Profiles in Computer Science Courage   Find  Your Passion “Not every computer scientist will fall in love with the field like I did,...
Apr, 01, 2011
Dissolving a Viral Capsid

Watching the beginning of the infection process in the longest and biggest virus simulation to date.

After a satellite tobacco necrosis virus particle infects a cell, it sheds the calcium ions that hold the capsid proteins together. Next, the proteins start to repel each other, the capsid swells and...
Jun, 06, 2012
Art of the Heart

 

 

  “The creative scientist studies nature with the rapt gaze of the lover, and is guided as often by aesthetics as by rational considerations in guessing how nature works.”—...
Jan, 01, 2006
Jackson Pollock’s Protein Interaction Communities

Plot shows how functional communities in yeast protein interaction networks change in size and nature at different levels of resolution

Splashes of bold color seem to drip down the page, bringing to mind the paintings of Jackson Pollock. Spurred by the beauty of the image she had created, Anna Lewis,* a graduate student studying...
protein interaction networks
Apr, 01, 2011
3D Radiology—Who Knew It Could Look So Good

3D images help physicians design appropriate interventions.

Images of realistic and colorful 3D human body parts line the hall outside the lab. Blood and muscle look like blood and muscle; bone looks like bone. You almost expect to find human cadavers being...
cardiovascular, radiology, stent, visualization
Sep, 01, 2011
Trajectory Optimization and Physical Realism

How adding jet packs to characters' hands can help optimize animations

An animated human figure seeking the optimal path from point A to point B typically relies on computationally expensive hard constraints that force the trajectories to be physically realistic. But...
Jun, 20, 2013
Packing It All In: Curricula for Biomedical Computing

Balancing Breadth and Depth

The last decade saw a proliferation of training programs at the intersection of life science and computation, with more than 60 new degree and certificate programs launched in the United States alone...
Sep, 01, 2005
Building RNA 3-D Structure
The structure of RNA is an important key to its function—including its role in disease. However, the structure of most RNAs is unknown because their extreme flexibility and high charge...
Mar, 01, 2009
A Tipping Point for Function Prediction
There comes a tipping point in systems-biology studies of gene function where knowing some genes’ functions can, using a computational approach, help hone in on the functions of other genes....
Apr, 01, 2010
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