Contests involving algorithms for protein structure prediction, natural language processing, and computer-aided disease detection are giving researchers a jolt of adrenalin and moving these fields forward
From all parts of the computational spectrum, researchers are duking it out: They are throwing their algorithms into the ring to see which one will out-perform all others on a particular task....
Jul, 01, 2006
Automated Function Prediction conference launches a new field
At the birth of a new field, a conference can act as a midwife, making sure the infant enters the world smoothly. Such was the case for the Automated Function Prediction (AFP) conference held at the...
Jan, 01, 2007
In science, there is a need to balance research in domain sciences and the infrastructure to support that research. Basic research mediated through peer review is understood to produce useful...
Jan, 01, 2007
POINT/
NO: Grant applications for the development and maintenance of software and infrastructure should compete with basic research applications.
Biomedicine has a strong...
Jul, 01, 2009
Researcher coaxes long strands of DNA into predetermined geometric shapes
Designing nanostructures of DNA just got easier. Paul Rothemund, PhD, a senior research fellow at Caltech has found a way to coax a long strand of DNA into a predetermined geometric shape by mixing...
Jul, 01, 2006
Structure-prediction algorithm searches for most likely conformation
If you want to find a Tab ‘A’ that will fit into a Slot ‘B’, you’ll waste a lot of time if you don’t know the shape of the slot. For scientists trying to design...
Jul, 01, 2006
Using Rosetta@Home, a program that runs on the personal computers of 150,000 volunteers worldwide, David Baker’s team predicted the structure of a 112-amino-acid protein from scratch.
When nature folds an amino acid sequence into a protein, it usually knows that just one conformation is the right one. But when a computer tries to do the same thing, it often predicts multiple...
Jan, 01, 2008
Supercomputers open up new horizons, offering the possibility of discovering new ways to understand life’s complexity
Their very names sound like dinosaurs. Teracomputers. Petacomputers. These are, in fact, the dinosaurs of the digital world—monstrous, hungry and powerful. But unlike the extinct...
Oct, 01, 2006
As algorithms evolve, computing power explodes, and scientists solve a greater number of 3-D protein structures, computer-aided design has the potential to dramatically cut the cost and time of drug discovery
Once upon a time, not long ago, HIV/AIDS was a scourge, killing anyone who contracted the deadly virus. Now, many people are living with the disease, which they control with drugs initially developed...
Jul, 01, 2007
Advances in computational power and algorithms have led to longer and more accurate molecular dynamics simulations of protein folding. But these approaches, because they are computationally intensive...
Jun, 06, 2012
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