The antiviral drugs Tamiflu and Relenza target a key flu protein—neuraminidase—preventing it from doing its job of releasing virus particles from infected cells into the body. The type of...
Jul, 01, 2009
A ten-year, $600-million program known as the Protein Structure Initiative (PSI) has already, in its five year pilot phase, greatly increased the speed at which protein structures can be determined,...
Jun, 01, 2005
POINT/
NO: Grant applications for the development and maintenance of software and infrastructure should compete with basic research applications.
Biomedicine has a strong...
Jul, 01, 2009
A recognition of biocomputing's successes and a prediction of what's to come
The last ten years have seen huge leaps in biomedical computing. We now have new ways to integrate and understand vast quantities of data; the capacity for multi-scale biological modeling; and a...
bioinformatics tools, biomedical computing, CAD, computational modeling, data mining, disease surveillance, dynamic modeling, education, eric jakobsson, function prediction, genetic association, genome annotation, in silico screening, medical informatics, neuromodeling, prosthetics, sequence alignment, structure prediction, systems biology, systems biomedicine, telemedicine, tomography
Jun, 01, 2005
Computers and human experts duke it out over who is better at diagnosing disease, interpreting images, or predicting protein structure
Dorothy Rosenthal tenses over her microscope, peering at the problematic nucleus on the Pap smear yet again. “It’s abnormal,” she decides, and then hesitates. “No, it’s...
Jul, 01, 2006
Connectivity Map helps connect drugs and diseases
Normal cells, diseased cells and cells on drugs share a common language: They all produce their own patterns of gene expression. And the patterns can be compared in useful ways—given a disease...
Jan, 01, 2007
Disentangling the different types of skeptics and what modelers can learn from each.
What are the telltale signs of a modeling talk at a biology conference? Just look for the sighs, shifting, and eye-rolling in the audience, says Donald C. Bolser, PhD, professor of physiological...
Jun, 05, 2012
Molecular dynamics simulations spot alternative drug target
A blindside attack on HIV-1 protease might just combat drug-resistant strains of HIV, according to simulations run by researchers at the University of California, San Diego. When the simulations shut...
Oct, 01, 2010
Can the complexities of biology be boiled down to Amazon.com-style recommendations? The examples here suggest possible pathways to an intelligent healthcare system with big data at its core.
“We have recommendations for you,” announces the website Amazon.com each time a customer signs in.
This mega-retailer analyzes billions of customers’ purchases—nearly $...
Jan, 02, 2012
From hardened software to scientific productivity, the NCBCs have changed the landscape for biomedical computing. What will happen when their funding expires?
It has been eight years since the National Institutes of Health (NIH) funded the first National Centers for Biomedical Computing (NCBCs). With two or three years remaining in the program (...
Oct, 19, 2012