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Modeling Whorls of Leaves

Computer simulation helps explain how plants grow

The petals of every flower and the leaves sprouting from every plant stalk have characteristic arrangements, a phenomenon called phyllotaxis. For two centuries, botanists have puzzled over the force...
Jul, 01, 2007
Reaching Under the Hood of a 20-year-old Musculoskeletal Model

Confidence boost for modelers

It’s often said that all models are wrong, but some are useful. And one model that certainly falls in the “useful” category is the human lower-limb model that Scott Delp published...
Jun, 01, 2010
The Active Transport of Ideas

Researchers examine the connection between editorial boards of medical informatics and bioinformatics journals

How ideas spread gets at the very fabric of scholarly research and has been studied from many different angles.   Many studies examine person-to-person connectivity in social networks. Within a...
Jul, 01, 2007
Behind the Connectome Commotion

Exploring the current state of connectomics--in the midst of hype

Connectomics is having a moment. Following on the heels of genomics, proteomics, transcriptomics, metabolomics, and microbiomics, the latest “omic” to seize the spotlight is generating...
brain, connectome
Jun, 20, 2013
Modeling Sperm: The Finer Points of Fertilization

Navigating the oviduct and other mysteries

The essential elements of human fertilization are clear: sperm swim through the uterus, travel up the fallopian tube, and fertilize an egg. Not as well understood are the the nitty-gritty details of...
agent-based models, fertilization, sperm
Jun, 19, 2013
Simulating Crowded Cytoplasm

Model fits experimental evidence

In biology textbooks, the carefully rendered cross-section of an E. coli cell often resembles a well-organized and spacious apartment, with everything in its place and ample room for movement. But a...
Jun, 01, 2010
The Institute for Systems Biology

Pursuing the frontiers of systems biology in an interdisciplinary, non-academic enviroment

The Institute for Systems Biology (ISB) was founded in Seattle, Washington in 2000 by Leroy Hood, MD, PhD, Alan Aderem, PhD, and Reudi Aebersold, PhD. Five years later, they are pursuing the...
Apr, 01, 2006
Resolution Limits of Optical Microscopy and the Mind

How precise an image can fluorescence microscopy provide?

As modern optics and cell biology have flourished in recent years, they’ve each driven innovation in the other. Yet commonly employed imaging techniques, such as fluorescence microscopy, have...
fluorescence, microscopy
Sep, 01, 2011
Meet the Skeptics: Why Some Doubt Biomedical Models - and What it Takes to Win Them Over

Disentangling the different types of skeptics and what modelers can learn from each.

What are the telltale signs of a modeling talk at a biology conference? Just look for the sighs, shifting, and eye-rolling in the audience, says Donald C. Bolser, PhD, professor of physiological...
Jun, 05, 2012
Prototype to Release: Software Engineering for Scientific Software

Set objectives and follow through

Having engineered several scientific software applications for public consumption, the authors know from experience that the process offers unique challenges. Typically, the algorithms being...
Oct, 22, 2012
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