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A Model Neuron
For patients suffering from nerve damage, neural regeneration is a faint hope. It rarely happens naturally, and attempts to coax new growth often fail. Researchers are trying to develop scaffolds to...
Apr, 01, 2009
Parkinson’s Culprit Modeled

A computational model of alpha-synuclein as it aggregates

Under a microscope, the curious protein clumps that dot the brains of Parkinson’s patients stick out like the culprits they are. But no one has yet caught the protein—alpha-synuclein...
Jul, 01, 2007
BENCH-SIDE COMPUTATION: New Tools to Accelerate Experimental Research

It’s impossible to predict what the hottest new tools will be, but here are a few gems that caught our attention

Many experimental researchers rely on computational tools to push the pace and productivity of laboratory research. It’s impossible to predict what the hottest new tools will be, but this...
protein dynamics, simulation, visual system
Apr, 01, 2011
An Uphill Challenge
RunBot, already the world’s fastest bipedal robot, has now also learned to keep its balance when walking up ramps. “We have achieved a synthesis of different functionalities, between...
Oct, 01, 2007
Different But Equal
Kids often claim they are just as smart—if not smarter—than their parents. Childish nonsense? Perhaps not, according to a recent study. It turns out that young children’s brains are...
Oct, 01, 2009
Smoking Addiction Explained

Putting neural and behavioral information together to model addiction

To non-smokers, the nasty-smelling habit is inexplicable. But now neurocomputational researchers have developed a hypothetical model to explain how nicotine produces addictive behavior. The first...
Apr, 01, 2006
Decoding Promotion
Despite their identical genomes, cells in the body develop distinct personalities—become neurons or liver cells, for instance—due to differences in gene expression. The mechanism that...
Apr, 01, 2009
Simulating Cells in Context: Bringing Mechanics Into Play
Like humans, cells are affected by their physical environment, their neighbors, the context in which they exist. Much research has focused on the chemical signals that control cell behavior. But...
developmental biology
Sep, 01, 2011
Computing the Ravages of Time: Using Algorithms To Tackle Alzheimer’s Disease

Biomarker research, genetics, and imaging are all coming into play

In 1906, at a small medical meeting in Tübingen, Germany, physician Alois Alzheimer gave a now-famous presentation about a puzzling patient. At age 51, Auguste D.’s memory was failing...
Oct, 01, 2007
Janelia Farm: Cultivating Scientists

Janelia farmers pursue novel, cross-disciplinary collaborations to work on long-term, unwieldy scientific problems difficult to tackle in a single laboratory

The folks at Howard Hughes Medical Institute who dreamed up Janelia Farm say it is as much a social innovation as a scientific one. “We are creating a different culture here,” says Gerald...
Jul, 01, 2006
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