There is growing recognition that epigenetics may be just as important as genetics in human health and disease.
In the early 19th century, Jean-Baptiste Lamarck explained evolution as the inheritance of acquired traits; he believed that changes due to behaviors and exposures in one generation could be passed...
Jun, 01, 2010
Exploring the current state of connectomics--in the midst of hype
Connectomics is having a moment. Following on the heels of genomics, proteomics, transcriptomics, metabolomics, and microbiomics, the latest “omic” to seize the spotlight is generating...
Jun, 20, 2013
Profiles in Computer Science Courage Part I: Reflections on the rewards of plunging into biomedicine
Interviews with Leonidas Guibas, Ron Shamir, Michael Black, David Haussler, Daphne Koller, Erin Halperin, Gene Myers, Paul Groth and Bruce Donald
To a computer scientist, the fields of biology and medicine can seem like the vast Pacific Ocean, says Leonidas Guibas, PhD, professor of computer science at Stanford University. “You go to the...
Apr, 01, 2011
Janelia farmers pursue novel, cross-disciplinary collaborations to work on long-term, unwieldy scientific problems difficult to tackle in a single laboratory
The folks at Howard Hughes Medical Institute who dreamed up Janelia Farm say it is as much a social innovation as a scientific one. “We are creating a different culture here,” says Gerald...
Jul, 01, 2006
Competition inspires model improvements
During the summer of 2009, the International Neuroinformatics Coordinating Facility in Stockholm dangled a nearly $10,000 cash prize in front of neuron modelers and challenged them to do better. And...
Jan, 01, 2010
A new technique for measuring neuronal activity on a chip
Neurons are tough cells to study. There are a staggering number of them in most animals, and they are constantly talking with one another. One way to look at groups of neurons in real-time is to take...
Oct, 01, 2010
In science, there is a need to balance research in domain sciences and the infrastructure to support that research. Basic research mediated through peer review is understood to produce useful...
Jan, 01, 2007
A recognition of biocomputing's successes and a prediction of what's to come
The last ten years have seen huge leaps in biomedical computing. We now have new ways to integrate and understand vast quantities of data; the capacity for multi-scale biological modeling; and a...
bioinformatics tools, biomedical computing, CAD, computational modeling, data mining, disease surveillance, dynamic modeling, education, eric jakobsson, function prediction, genetic association, genome annotation, in silico screening, medical informatics, neuromodeling, prosthetics, sequence alignment, structure prediction, systems biology, systems biomedicine, telemedicine, tomography
Jun, 01, 2005
Computation helps evaluate the nature of the NIH research portfolio in ways that were previously very difficult.
What biomedical research does the federal government fund? How is it allocated across important diseases? Has that changed over time? Answering these questions at any level of detail is tougher than...
Jun, 08, 2012
Using computational models, researchers are gaining traction toward understanding what makes a stem cell a stem cell; how gene expression drives stem cell differentiation; why studying stem cell heterogeneity is important; and, ultimately, how stem cells control their fate.
To the casual observer, stem cells offer the almost magical promise of—Voila!—turning into exactly the kind of cell needed to repair an injured spinal cord or replace a damaged organ. And...
Apr, 01, 2010
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