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On Your Mark, Get Set, Build Infrastructure: The NCBC Launch

The first four National Centers for Biomedical Computing take off

WHY NATIONAL CENTERS? Four National Centers for Biomedical Computing were launched by the NIH in 2004 with $20 million in funding for each center over five years. The reason: We need to make...
Jun, 01, 2005
Dogs, Doses, and Devices: The FDA's Ambitious Plans for Computational Modeling

Computational modeling can help fill gaps in how we develop and review new drugs and devices

What role does computational modeling play at the United States Food and Drug Administration (FDA)?  If you ask Paul Watkins, MD, director of the Hamner—University of North Carolina...
devices, drug discovery, FDA, modeling
Sep, 01, 2011
Simulation Simplified

Simbody introduces the concept of a “mobilizer,” which directly expresses a part’s movement, however complex, purely in relation to another part

Typically, researchers who simulate life in motion—from particles to people—start by describing the motion of each part of an object independently of the other parts. Additional equations...
Jan, 01, 2008
Putting Technology In Its Place
When you step on the gas pedal, you expect acceleration (and lots of it). Stomp on the brake to come safely to a stop in the rain. Finger the power-assisted steering wheel and the car obeys. Make a...
Oct, 01, 2009
A Big Step Forward for OpenSim

OpenSim 2.0 promises greater opportunities for customization

With its initial release two years ago, OpenSim offered researchers a powerful open-source application for simulating movement. Simple enough to be used by high school students yet advanced enough to...
Jan, 01, 2010
Talking Heads

A physically-based facial muscle model for animation

He speaks: “Algorithm.” And you can just about read his lips.   The movie was created using muscle-driven physics-based animation. Other techniques might produce images that look...
Oct, 01, 2007
Fluid Code
In 1999, Mark J. Stock, PhD, took his first accidental step toward becoming an artist. He used a 3-D rendering program to help him debug some code. “The first image that came out was beautiful...
Jan, 01, 2010
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Jun, 13, 2012
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Sep, 01, 2009
Predicting Protein Complexes

A combination of genomics data and molecular dynamics modeling is sufficient to predict protein complex structure

The zone where two proteins interact presents a possible target for drug design. But identifying possible drugs requires a detailed understanding of the interface between the proteins. Computer...
Apr, 01, 2010
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