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The Eyes Have It: Biomechanical Models Explore Disorders of the Eye

Biomechanical models contribute to a better understanding of both the normal and the diseased eye.

Squint, and you can almost  make out that bird soaring over the horizon. But determining whether it’s a hawk or a raven will be nearly impossible for someone with myopia, also known as...
Feb, 19, 2013
Imaging Collections: How They're Stacking Up

As barriers to massive imaging collections fall, researchers can look at human systems in their entirety rather than in pieces

In the beginning there was the Visible Human. It broke new ground by gathering some 2,000 serial images from a death row inmate’s cadaver, and was the first time researchers had sectioned a...
Jul, 01, 2007
Computing the Ravages of Time: Using Algorithms To Tackle Alzheimer’s Disease

Biomarker research, genetics, and imaging are all coming into play

In 1906, at a small medical meeting in Tübingen, Germany, physician Alois Alzheimer gave a now-famous presentation about a puzzling patient. At age 51, Auguste D.’s memory was failing...
Oct, 01, 2007
Betting on Genome Interpretation

Six startups jockey for a place at the table. Who will succeed?

A handful of startups are wagering that genome interpretation is the next big thing.    Why is this business space so hot?  “Once you can produce a better faster genome, thanks...
Jun, 20, 2013
Twin Curses Plague Biomedical Data Analysis

How to deal with too many dimensions and too few samples.

Noninvasive experimental techniques, such as magnetic resonance (MR), infrared, Raman and fluorescence spectroscopy, and more recently, mass spectroscopy (proteomics) and microarrays (genomics) have...
Sep, 01, 2005
A Finer Fat Model

Models of healthy and diseased lipid profiles could prove valuable diagnostically.

When it comes to heart disease risk, “bad” and “good” cholesterol—also known as low density lipoproteins [LDL] and high density lipoproteins [HDL]—do not tell...
Oct, 01, 2008
Zooming In on Blood Coagulation and Viscosity: Computation Takes On Blood Behavior

Simulations illuminate the inner workings of blood at multiple levels

Understanding blood flow and coagulation is crucial to treating blood disorders such as hemophilia and thrombosis, and to dealing with diseases such as AIDS, malaria, and diabetes that have...
Jun, 07, 2012
Flexible Molecular Computer Functions Inside a Cell
A newly created molecular computer works in human cells and offers the flexibility of a general-purpose circuit. The advance, described in Nature Biotechnology in May, brings closer the eventual...
Oct, 01, 2007
Dogs, Doses, and Devices: The FDA's Ambitious Plans for Computational Modeling

Computational modeling can help fill gaps in how we develop and review new drugs and devices

What role does computational modeling play at the United States Food and Drug Administration (FDA)?  If you ask Paul Watkins, MD, director of the Hamner—University of North Carolina...
devices, drug discovery, FDA, modeling
Sep, 01, 2011
Simbios: Bringing Biomedical Simulation to Your Fingertips

How Simbios' state-of-the-art software tools are contributing to high-impact biomedical research

Simbios began with a simple idea: that physics-based simulation of biological structures at all scales could benefit from a unified tool-building effort.   At the same time, the thinking went,...
Oct, 01, 2009
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