In science, there is a need to balance research in domain sciences and the infrastructure to support that research. Basic research mediated through peer review is understood to produce useful...
Jan, 01, 2007
The importance of developing and deploying tools for the quantitative clinician scientist
The word Om (or Aum) has many meanings in ancient Hindu philosophy, one of which is “that which contains all other sounds.” The meaning has relevance to the now commonly used suffix...
Jun, 01, 2010
Helping newcomers understand the lay of the land
As a program manager in biomedical computing and computational biology at the National Institutes of Health, I field many questions, particularly from new investigators. They ask questions like:...
Apr, 01, 2010
Today, the knowledge, experience and memory of clinicians or scientists function as the exclusive resource for distinguishing normal from abnormal brain images; identifying signatures or biomarkers...
Jul, 01, 2009
Dear Reader,
In this eighteenth issue of Biomedical Computation Review (BCR), we bring you a special edition devoted to the work of the magazine’s publisher: the Simbios National Center...
Oct, 01, 2009
Modelers should take the lead.
Many collaborators 1 with whom modelers2 work have little or no training in modeling3 and so it is natural that they may be cautious,...
Jun, 05, 2012
For major team-based Roadmap initiatives, National Institutes of Health (NIH) officials expect grantees to look beyond the focus of their individual projects to build bridges not only among funded...
Oct, 01, 2008
The Human Genome Project has spurred extraordinary developments in our ability to characterize cellular systems in high-throughput fashion. Polymorphism, methylation, gene expression, and proteomics...
Apr, 01, 2008
How errors in data, software, and methodology can teach us how to do better
In 2006, a paper in Nature Medicine suggested a novel and potentially revolutionary method for predicting patient responses to cancer therapies using gene signatures. The finding piqued the interest...
Sep, 01, 2011
Supercomputers open up new horizons, offering the possibility of discovering new ways to understand life’s complexity
Their very names sound like dinosaurs. Teracomputers. Petacomputers. These are, in fact, the dinosaurs of the digital world—monstrous, hungry and powerful. But unlike the extinct...
Oct, 01, 2006