For major team-based Roadmap initiatives, National Institutes of Health (NIH) officials expect grantees to look beyond the focus of their individual projects to build bridges not only among funded...
Oct, 01, 2008
The Human Genome Project has spurred extraordinary developments in our ability to characterize cellular systems in high-throughput fashion. Polymorphism, methylation, gene expression, and proteomics...
Apr, 01, 2008
The Principal Investigators weigh in
Ever since the National Institutes of Health (NIH) began funding the National Centers for Biomedical Computing (NCBCs) just over seven years ago, these powerhouses have been plugging away, building...
Feb, 29, 2012
Transparent peer review, replication studies, and journals of negative results all suggest change is on the horizon
As I was writing this editorial, I learned about yet another scientific paper being retracted. This time it was a genetics paper in Science, one of the hundreds of retractions that the blog...
Sep, 01, 2011
The new Big Data to Knowledge (BD2K) program signals NIH's faith in computational research
In December, the National Institutes of Health (NIH) approved a new trans-NIH initiative called Big Data to Knowledge (BD2K). With this action, the NIH signals its intention to invest a significant...
Feb, 19, 2013
Dear Reader:
Welcome to the first issue of Biomedical Computation Review. With this quarterly publication, we hope to inspire and bring together scientists from the many fields that touch on...
Jun, 01, 2005
Defining biomedical computation
Looking back at some of the intellectual achievements of the last half century, it is clear that humankind has made tremendous progress in many areas, but arguably none more so than in the two areas...
Jun, 01, 2005
About this issue of Biomedical Computation Review
One of the main goals of this magazine is to create and foster a sense of community among the diverse disciplines that make up biomedical computation (hence our tagline: diverse disciplines, one...
Sep, 01, 2005
Computer models find that various ion channel arrangements can produce the same firing pattern
Each cell in our nervous system is an instrument in a complex symphony of electrophysiologic communication. A neuron’s signaling abilities arise from its array of ion channels—tunnels...
Jan, 01, 2007
New approaches extend multiscale models to represent cellular mesoscales and bridge from molecular to cellular models
In an era of increasingly comprehensive molecular characterizations of living systems, computation has emerged as a key technology to facilitate integrative understanding of biological mechanisms....
Feb, 19, 2013