The Salivary Proteome Knowledge Base
If spit could talk, it might tell us whether we’re sick or healthy.
According to David Wong, DMD, DMSc—professor and associate dean of research at the School of Dentistry at the...
Jun, 01, 2005
Watching changes over time
These days, molecular biologists often gather data over a period of time—observing shifts as they occur inside groups of cells undergoing natural changes. The researchers then face the daunting...
Jun, 01, 2010
Decades of steady progress in pharmacogenetics have unearthed hundreds of associations between genes and drug response. But the field has to solve some theoretical and practical issues before it can deliver on the promise of personalized drug therapy.
As algorithms go, it’s deceptively simple. Just add together eight weighted pieces of patient information—age, height, weight, race, data about two genes, and a pair of clinical...
Jul, 01, 2009
iHOP organizes interconnected information
Text-mining tools such as iHOP (Information Hyperlinked Over Proteins) are doing for biological literature what hyperlinks and search engines do for the Internet: organizing interconnected...
Apr, 01, 2007
POINT/
Less than meets the eye ...
Oct, 05, 2012
The National Institutes of Health Roadmap for Medical Research has recently completed the first stage of an ambitious program to expand the computational infrastructure and software tools needed to...
Jan, 01, 2006
Incremental progress and measured successes
Personalized cancer therapy is now a reality. A handful of tumor-classifying tests and targeted drugs are in widespread clinical use; and early attempts are underway to match high-risk cancer...
Jan, 02, 2012
The Human Genome Project has spurred extraordinary developments in our ability to characterize cellular systems in high-throughput fashion. Polymorphism, methylation, gene expression, and proteomics...
Apr, 01, 2008
We are crawling with bugs. It might even be better to say that we are bugs. For every human cell in our bodies there may be ten or even a hundred other cells that aren’t human at all. Yet many...
Apr, 01, 2008
Despite their identical genomes, cells in the body develop distinct personalities—become neurons or liver cells, for instance—due to differences in gene expression. The mechanism that...
Apr, 01, 2009