Cancer proteins highly interactive
New research suggests that cancer proteins, like influential people, have the most connections. These results, from an extensive study of how human proteins interact with one another, could help...
Jan, 01, 2007
Computing airflow dynamics
We can’t see them, but tiny particles—dust, pollen, microbes, and the like—swirl around us in complicated, turbulent pathways. New numerical simulations suggest that, at least in...
Jun, 01, 2010
How cell-centered models are adding fundamental insights into our understanding of cell behaviors
The cell is like our financial system: Even if you have a diagram of all the complex interactions going on, you still cannot intuit how the whole system will react when perturbed. Indeed, the cell...
Apr, 01, 2010
New approaches extend multiscale models to represent cellular mesoscales and bridge from molecular to cellular models
In an era of increasingly comprehensive molecular characterizations of living systems, computation has emerged as a key technology to facilitate integrative understanding of biological mechanisms....
Feb, 19, 2013
Computational simulations of life in motion at every scale—molecular, cellular, tissue-level, and whole organism—are boosting our understanding of the role mechanics plays in controlling life.
From atoms and molecules to insects, dinosaurs, and humans, computational researchers are finding that much of life can be understood in mechanical terms. Indeed, the machines of life are...
Jan, 01, 2008
Computer models find that various ion channel arrangements can produce the same firing pattern
Each cell in our nervous system is an instrument in a complex symphony of electrophysiologic communication. A neuron’s signaling abilities arise from its array of ion channels—tunnels...
Jan, 01, 2007
A grant to develop software tools to analyze how neurons distribute themselves within the brain
Do neurons need personal space like people in an elevator? Are they influenced by their neighbors or do they randomly find a home in the brain? If the arrangement is patterned, what is the cause of...
Jun, 01, 2005
Balancing Breadth and Depth
The last decade saw a proliferation of training programs at the intersection of life science and computation, with more than 60 new degree and certificate programs launched in the United States alone...
Sep, 01, 2005
Affinity propagation clusters lots of different kinds of data better and faster than other methods
Starting in preschool we all learn how to get organized. Typically, we start with pre-determined categories (dolls, trains, blocks); pre-set ideas about what belongs in each category (Barbie: doll;...
Jul, 01, 2007
For a century, neuroscientists have dissected, traced, eavesdropped on, and are now compiling a seemingly endless cast of players in the nervous system. As we keep gathering more and more molecular...
Apr, 01, 2009