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Computing the Ravages of Time: Using Algorithms To Tackle Alzheimer’s Disease

Biomarker research, genetics, and imaging are all coming into play

In 1906, at a small medical meeting in Tübingen, Germany, physician Alois Alzheimer gave a now-famous presentation about a puzzling patient. At age 51, Auguste D.’s memory was failing...
Oct, 01, 2007
From Sight to Insight: Visualization tools yield biomedical success stories
They're more than just pretty pictures adorning office walls and presentation slides. Beamed into operating room computer monitors, they're guiding the scalpels of brain surgeons. Dancing...
Jan, 01, 2012
NewsBytes: Winter 2005-2006
T-Rex in the Slow Lane by Kristen Cobb   Tyrannosaurus rex is often pictured baring its teeth, crouching, and running swiftly after its prey, but these images are largely based on human fancy...
Jan, 01, 2006
On Your Mark, Get Set, Build Infrastructure: The NCBC Launch

The first four National Centers for Biomedical Computing take off

WHY NATIONAL CENTERS? Four National Centers for Biomedical Computing were launched by the NIH in 2004 with $20 million in funding for each center over five years. The reason: We need to make...
Jun, 01, 2005
A Tipping Point for Function Prediction
There comes a tipping point in systems-biology studies of gene function where knowing some genes’ functions can, using a computational approach, help hone in on the functions of other genes....
Apr, 01, 2010
A Crescendo of Protein Structures
A ten-year, $600-million program known as the Protein Structure Initiative (PSI) has already, in its five year pilot phase, greatly increased the speed at which protein structures can be determined,...
Jun, 01, 2005
The BiGG Picture

A virtual metabolic network represents intracellular traffic

It’s hard to imagine a map depicting the daily flow of traffic on water, wheels and foot throughout San Diego—or any large city—over the course of a day. “That map can...
Apr, 01, 2007
Tools to Understand the Federal Research Portfolio: From Ontologies to Topic Mapping

Computation helps evaluate the nature of the NIH research portfolio in ways that were previously very difficult.

What biomedical research does the federal government fund? How is it allocated across important diseases? Has that changed over time? Answering these questions at any level of detail is tougher than...
Jun, 08, 2012
An insider’s view of biological structures
In March, Simbios released version 1.0 of the SimTK Simulation toolkit. A cornerstone of this release is Simbody, a new piece of the open-source SimTK Core toolkit for physics-based simulation....
Apr, 01, 2008
Getting It Right: Better Validation Key to Progress in Biomedical Computing

Bringing models closer to reality

When the ill-fated space shuttle Columbia launched on January 16, 2003, a large piece of foam fell off and hit the left wing. Alerted of the impact, NASA engineers used a computer model to predict...
7009, competitions, outsource, self-assessment, validation
Oct, 19, 2012
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