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Bringing the Fruits of Computation to Bear on Human Health: It’s a Tough Job but the NIH Has to Do It
The National Institutes of Health are on a mission: To understand and tackle the problems of human health. To make that daunting problem approachable, 15 of the 20 institutes divvy up human health...
Oct, 05, 2012
Resolution Limits of Optical Microscopy and the Mind

How precise an image can fluorescence microscopy provide?

As modern optics and cell biology have flourished in recent years, they’ve each driven innovation in the other. Yet commonly employed imaging techniques, such as fluorescence microscopy, have...
fluorescence, microscopy
Sep, 01, 2011
Life in Motion: Simulation from Particles to People

Computational simulations of life in motion at every scale—molecular, cellular, tissue-level, and whole organism—are boosting our understanding of the role mechanics plays in controlling life.

From atoms and molecules to insects, dinosaurs, and humans, computational researchers are finding that much of life can be understood in mechanical terms. Indeed, the machines of life are...
Jan, 01, 2008
Window into Microbial Behavior

Metagenomes give a picture of the genes driving metabolic processes important to bacterial growth and survival in different environments.

We know they are there, but most microbial denizens of deep oceans, sea floor vents, even our own intestines, remain a mystery. Because most microbes won’t grow in the lab, researchers have few...
Jul, 01, 2008
Simbios: Bringing Biomedical Simulation to Your Fingertips

How Simbios' state-of-the-art software tools are contributing to high-impact biomedical research

Simbios began with a simple idea: that physics-based simulation of biological structures at all scales could benefit from a unified tool-building effort.   At the same time, the thinking went,...
Oct, 01, 2009
Efficiently Evaluating Mathematical Expressions with OpenCL Code

A unique opportunity to build both flexibility and high performance into a piece of software.

OpenCL is a cross-platform language for doing general purpose computation on graphics processing units (GPUs) and other massively parallel architectures. One of its most interesting features is the...
Apr, 01, 2010
Ramping Up to Multiscale: Taking Biomedical Modeling to a New Level

Multi-scale modeling is now at what might be called its gestational stage

For centuries, mathematics has been an indispensable ally of the physical sciences and engineering. Planes fly and telephones work because engineers know how to simplify physical systems into...
Apr, 01, 2006
Continuum Mechanical Modeling of Biological Growth
Unlike most classical engineering materials, biological tissues can adapt to external stimuli by growing in volume: Skin grows in response to wounding; muscles grow in response to exercise; cancer...
Apr, 01, 2011
Scientific Discovery Through Video Games

"Fold-It" players find best protein conformations to fight cancer

When it comes to folding proteins, even modern supercomputers don’t always get things exactly right. Enter FoldIt, an online video game that harnesses the human brain’s natural pattern-...
Jan, 01, 2010
Getting It Right: Better Validation Key to Progress in Biomedical Computing

Bringing models closer to reality

When the ill-fated space shuttle Columbia launched on January 16, 2003, a large piece of foam fell off and hit the left wing. Alerted of the impact, NASA engineers used a computer model to predict...
7009, competitions, outsource, self-assessment, validation
Oct, 19, 2012
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