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Betting on Genome Interpretation

Six startups jockey for a place at the table. Who will succeed?

A handful of startups are wagering that genome interpretation is the next big thing.    Why is this business space so hot?  “Once you can produce a better faster genome, thanks...
Jun, 20, 2013
Bacteria Prepare Themselves

Microbes react to environmental changes before they occur.

When we see dark clouds, we might grab an umbrella before heading outside.  We’ve long believed that showing such foresight requires a brain and complex information-processing capability...
Oct, 01, 2008
Computing the Ravages of Time: Using Algorithms To Tackle Alzheimer’s Disease

Biomarker research, genetics, and imaging are all coming into play

In 1906, at a small medical meeting in Tübingen, Germany, physician Alois Alzheimer gave a now-famous presentation about a puzzling patient. At age 51, Auguste D.’s memory was failing...
Oct, 01, 2007
Editor's Picks Fall 2005

Open Source reflections; designing with code re-use; and Cygwin

Do you have a few favorite books that you recommend to anyone with an interest in biomedical computing? Are there software products or Web sites that you love to evangelize? We’d like to open...
Sep, 01, 2005
Smart Embedded Devices: Here They Come

Machine learning for an artificial pancreas and deep brain stimulation

Embedded medical devices that both detect symptoms and treat them have existed for decades. Take, for example, the heart pacemaker. But a new generation of implants could soon emerge to do something...
diabetes, epilepsy, machine learning, pancreas, Parkinsons
Oct, 19, 2012
Simbios: Bringing Biomedical Simulation to Your Fingertips

How Simbios' state-of-the-art software tools are contributing to high-impact biomedical research

Simbios began with a simple idea: that physics-based simulation of biological structures at all scales could benefit from a unified tool-building effort.   At the same time, the thinking went,...
Oct, 01, 2009
Computing Has Changed Biology Forever

And people are starting to notice

In 1991, a prescient editorial in Nature by Harvard’s Walter Gilbert, PhD, (“Towards a paradigm shift in biology”) included these observations on the utility and impact of computing...
Apr, 01, 2006
A Vision of Computational Anatomy
Today, the knowledge, experience and memory of clinicians or scientists function as the exclusive resource for distinguishing normal from abnormal brain images; identifying signatures or biomarkers...
Jul, 01, 2009
Clinical Decision Support: Providing Quality Healthcare with Help from a Computer
In a classic cartoon, a physician offers a second opinion from his computer.  The patient looks horrified: How absurd to think that a computer could have better judgment than a human doctor! But...
Jan, 01, 2010
An Unfolding Story

A model of chromatin explores how it folds and unfolds

To fit an organism’s DNA into a single cell, it has to be tightly compacted, first wound around proteins to form chromatin fibers, then further coiled into chromosomes. Computer simulations by...
Sep, 01, 2005
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