They've gone from hype to backlash. Now it's time for reality: How microarrays are being used to benefit healthcare
When DNA microarray technology emerged more than a decade ago, it was met with unbridled enthusiasm. By allowing scientists to look at the expression of enormous numbers of genes in the genome...
Oct, 01, 2006
In a classic cartoon, a physician offers a second opinion from his computer. The patient looks horrified: How absurd to think that a computer could have better judgment than a human doctor! But...
Jan, 01, 2010
In science, there is a need to balance research in domain sciences and the infrastructure to support that research. Basic research mediated through peer review is understood to produce useful...
Jan, 01, 2007
The National Institutes of Health Roadmap for Medical Research has recently completed the first stage of an ambitious program to expand the computational infrastructure and software tools needed to...
Jan, 01, 2006
Computing using time steps -- a necessary approximation
Time flows like a continuous, steady river. And it moves forward—never back. These facts create inherent challenges for computer simulations of biological molecules in motion.
It would...
Jun, 19, 2013
A debate
Say you are performing biomolecular investigations that are extremely compute intensive. You have a finite amount of money and time. You could get (1) a supercomputer (fast custom CPUs and high-speed...
Oct, 01, 2009
I'd like to pay homage to James Burke and his inspiring PBS show Connections by taking you on my own short journey of connected ideas.
The timeless game of chess has long been a grand challenge for artificial intelligence, with the number of possible games being much greater than the number of atoms in the universe. Baron...
Jan, 01, 2006
POINT/
NO: Grant applications for the development and maintenance of software and infrastructure should compete with basic research applications.
Biomedicine has a strong...
Jul, 01, 2009
A virtual metabolic network represents intracellular traffic
It’s hard to imagine a map depicting the daily flow of traffic on water, wheels and foot throughout San Diego—or any large city—over the course of a day. “That map can...
Apr, 01, 2007
They're more than just pretty pictures adorning office walls and presentation slides. Beamed into operating room computer monitors, they're guiding the scalpels of brain surgeons. Dancing...
Jan, 01, 2012