Set objectives and follow through
Having engineered several scientific software applications for public consumption, the authors know from experience that the process offers unique challenges. Typically, the algorithms being...
Oct, 22, 2012
Each year, the American Association for the Advancement of Science (AAAS) gives an award to an outstanding paper that appeared in the pages of Science. This year the award—the Newcomb Cleveland...
Jun, 01, 2005
Using computation, researchers narrow the search space for directed evolution; guide mutagenesis; and create de novo enzymes
Enzymes are among nature’s crowning achievements: they accelerate chemical reactions, making life possible. People have co-opted natural enzymes for industrial use for thousands of years (think...
Feb, 19, 2013
Working in silico, researchers hone in on candidate proteins worthy of laboratory work
By stringing together amino acids in a prescribed sequence that then folds into a defined structure, nature designs proteins to perform specific functions. Nowadays, computational researchers are...
Sep, 01, 2011
Balancing Breadth and Depth
The last decade saw a proliferation of training programs at the intersection of life science and computation, with more than 60 new degree and certificate programs launched in the United States alone...
Sep, 01, 2005
Bioinformatics and computational biology have told us a lot about biology—primarily that we know so little. Advances have led to many more unanswered questions, suggesting we know less and less...
Oct, 01, 2007
Li Niu of the University of Albany works with Simbios to understand an unusual RNA.
from http://biomedicalcomputationreview.org/content/simbios-bringing-biomedical-simulation-your-fingertips
Li Niu, PhD, associate professor of chemistry at the University of Albany, SUNY found...
Oct, 01, 2009
As algorithms evolve, computing power explodes, and scientists solve a greater number of 3-D protein structures, computer-aided design has the potential to dramatically cut the cost and time of drug discovery
Once upon a time, not long ago, HIV/AIDS was a scourge, killing anyone who contracted the deadly virus. Now, many people are living with the disease, which they control with drugs initially developed...
Jul, 01, 2007
Moving from intuition to evidence-based intervention
To understand how muscles contract and joints flex, researchers have dissected cadavers and experimented with animals. They can describe how bones, muscles, and tendons connect in a complicated...
Jan, 01, 2007
Machine learning for an artificial pancreas and deep brain stimulation
Embedded medical devices that both detect symptoms and treat them have existed for decades. Take, for example, the heart pacemaker. But a new generation of implants could soon emerge to do something...
Oct, 19, 2012