Bringing models closer to reality
When the ill-fated space shuttle Columbia launched on January 16, 2003, a large piece of foam fell off and hit the left wing. Alerted of the impact, NASA engineers used a computer model to predict...
Oct, 19, 2012
Erik Lindahl of Stockholm University uses OpenMM to speed up molecular simulations of membrane proteins and takes inspiration from Simbios’ professional approach to software development as he continues developing and maintaining GROMACS.
from http://biomedicalcomputationreview.org/content/simbios-bringing-biomedical-simulation-your-fingertips
Simbios provides two key benefits to Erik Lindahl, PhD, associate professor of...
Oct, 01, 2009
The antiviral drugs Tamiflu and Relenza target a key flu protein—neuraminidase—preventing it from doing its job of releasing virus particles from infected cells into the body. The type of...
Jul, 01, 2009
How Tat crosses the lipid bilayer--with help from the bilayer.
A powerful snippet of protein called the Tat peptide ferries itself across cell membranes dragging just about anything it’s attached to along with it. How it accomplishes this feat has been a...
Jul, 01, 2008
Jill Higginson at the University of Delaware uses OpenSim to study stroke.
from http://biomedicalcomputationreview.org/content/simbios-bringing-biomedical-simulation-your-fingertips
Jill Higginson, PhD, assistant professor of mechanical engineering at the University...
Oct, 01, 2009
How cell-centered models are adding fundamental insights into our understanding of cell behaviors
The cell is like our financial system: Even if you have a diagram of all the complex interactions going on, you still cannot intuit how the whole system will react when perturbed. Indeed, the cell...
Apr, 01, 2010
A combination of genomics data and molecular dynamics modeling is sufficient to predict protein complex structure
The zone where two proteins interact presents a possible target for drug design. But identifying possible drugs requires a detailed understanding of the interface between the proteins. Computer...
Apr, 01, 2010
Simulations illuminate the inner workings of blood at multiple levels
Understanding blood flow and coagulation is crucial to treating blood disorders such as hemophilia and thrombosis, and to dealing with diseases such as AIDS, malaria, and diabetes that have...
Jun, 07, 2012
HAP-SAMPLE takes real data as the template for simulations
Trying to find the genetic causes of a human disease requires lots of data. These days, researchers scan the genomes of people who do and don’t have a particular disease and look for genome-...
Jan, 01, 2008
2004 grant to create a 3-D model of the respiratory tract
In September 2004, researchers at Pacific Northwest National Laboratory (PNNL) in Richland, Washington, received a $10 million grant to create a three-dimensional imaging and computer model of how...
Jun, 01, 2005