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Computational Biology Catches the Flu: Modeling the bug, the host, the world
The flu virus is an evolutionary marvel. Teams of experts design an appropriate flu vaccine annually just to keep up with the microbe’s ability to evade the human immune system. Multiple...
Jul, 01, 2006
BENCH-SIDE COMPUTATION: New Tools to Accelerate Experimental Research

It’s impossible to predict what the hottest new tools will be, but here are a few gems that caught our attention

Many experimental researchers rely on computational tools to push the pace and productivity of laboratory research. It’s impossible to predict what the hottest new tools will be, but this...
protein dynamics, simulation, visual system
Apr, 01, 2011
Ontologies: A Way of Capturing and Representing Knowledge
Ontology, defined as "a theory of existence," has an important place in Western philosophy. It seeks to account for all phenomena in the universe.   In biomedical computation, however...
Jan, 01, 2006
Profiles in Computer Science Courage Part II: Advice on Taking the Plunge
Words of Advice from the Scientists Featured in Profiles in Computer Science Courage   Find  Your Passion “Not every computer scientist will fall in love with the field like I did,...
Apr, 01, 2011
Editor's Picks
One of our goals at Biomedical Computation Review is to create a sense of kinship among members of this very diverse community of researchers. This column provides reviews of some of the latest and...
Jun, 01, 2005
“Sloppy” Systems Biology

Many systems models are strikingly vulnerable to even small changes in the variables

Systems biologists seek to model many complex biological interactions all at once. Typically, they input tens or even hundreds of variables to produce predic- tions about a system—for example,...
Jan, 01, 2008
Error! – What Biomedical Computing Can Learn From Its Mistakes

How errors in data, software, and methodology can teach us how to do better

In 2006, a paper in Nature Medicine suggested a novel and potentially revolutionary method for predicting patient responses to cancer therapies using gene signatures. The finding piqued the interest...
publication, reproducible research, statistics, validation
Sep, 01, 2011
Getting It Right: Better Validation Key to Progress in Biomedical Computing

Bringing models closer to reality

When the ill-fated space shuttle Columbia launched on January 16, 2003, a large piece of foam fell off and hit the left wing. Alerted of the impact, NASA engineers used a computer model to predict...
7009, competitions, outsource, self-assessment, validation
Oct, 19, 2012
Reverse Engineering the Brain
For a century, neuroscientists have dissected, traced, eavesdropped on, and are now compiling a seemingly endless cast of players in the nervous system. As we keep gathering more and more molecular...
neuron, reverse engineer
Apr, 01, 2009
Tapping the Brain: Decoding fMRI

How researchers are predicting specific thoughts from brain activity

Revealing the brain’s hidden stash of pictures, thoughts, and plans has, until recently, been the work of parlor magicians. Yet within the last decade, neuroscientists have gained powerful...
fMRI, memories, multivoxel pattern analysis, MVPA, neuroscience
Jan, 02, 2012
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