Many systems models are strikingly vulnerable to even small changes in the variables
Systems biologists seek to model many complex biological interactions all at once. Typically, they input tens or even hundreds of variables to produce predic- tions about a system—for example,...
Jan, 01, 2008
Either/or molecular circuitry modeled
To differentiate or not to differentiate? That is the question constantly faced by embryonic stem cells. And they seem to answer it decisively at the behest of a molecular trio of transcription...
Jan, 01, 2007
Neighbor cells affect stem cell differentiation in computer simulation
Every generation, a few nonconformists crop up in tissue cultures of genetically identical cells. The question is: are the wayward simply born that way, or did something in the environment affect...
Jul, 01, 2007
How researchers are predicting specific thoughts from brain activity
Revealing the brain’s hidden stash of pictures, thoughts, and plans has, until recently, been the work of parlor magicians. Yet within the last decade, neuroscientists have gained powerful...
Jan, 02, 2012
Thirty years ago, molecular biologists routinely constructed protein models out of brass rods (“Kendrew models”). In recent years, researchers put away such tinker toys and turned to...
Aug, 31, 2005
A recognition of biocomputing's successes and a prediction of what's to come
The last ten years have seen huge leaps in biomedical computing. We now have new ways to integrate and understand vast quantities of data; the capacity for multi-scale biological modeling; and a...
bioinformatics tools, biomedical computing, CAD, computational modeling, data mining, disease surveillance, dynamic modeling, education, eric jakobsson, function prediction, genetic association, genome annotation, in silico screening, medical informatics, neuromodeling, prosthetics, sequence alignment, structure prediction, systems biology, systems biomedicine, telemedicine, tomography
Jun, 01, 2005
The availability of free and open access data, models, and software indisputably accelerates scientific progress. Unfortunately, dissemination necessitates organization, documentation, and quality...
Jan, 01, 2010
Using computational models, researchers are gaining traction toward understanding what makes a stem cell a stem cell; how gene expression drives stem cell differentiation; why studying stem cell heterogeneity is important; and, ultimately, how stem cells control their fate.
To the casual observer, stem cells offer the almost magical promise of—Voila!—turning into exactly the kind of cell needed to repair an injured spinal cord or replace a damaged organ. And...
Apr, 01, 2010
Many new drugs carry a risk that they will cause more problems than they cure. That’s because a drug intended to bind one protein might also bind others. In an effort to address that problem,...
Apr, 01, 2008
CompuCell-3D models behaviors rather than genes
Researchers have successfully simulated how growing blood vessels affect the sizes and shapes of tumors using a 3-D model based solely on how cells behave—without reference to intracellular...
Jan, 01, 2010