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OpenSim User Profile: B.J. Fregly, PhD

University of Florida’s B.J. Fregly hopes to use OpenSim to simulate the knee.

from http://biomedicalcomputationreview.org/content/simbios-bringing-biomedical-simulation-your-fingertips   B.J. Fregly, PhD, associate professor of mechanical and aerospace engineering and of...
Oct, 01, 2009
Binary Breathing

2004 grant to create a 3-D model of the respiratory tract

In September 2004, researchers at Pacific Northwest National Laboratory (PNNL) in Richland, Washington, received a $10 million grant to create a three-dimensional imaging and computer model of how...
Jun, 01, 2005
Modeling Sperm: The Finer Points of Fertilization

Navigating the oviduct and other mysteries

The essential elements of human fertilization are clear: sperm swim through the uterus, travel up the fallopian tube, and fertilize an egg. Not as well understood are the the nitty-gritty details of...
agent-based models, fertilization, sperm
Jun, 19, 2013
When Does Computational Validation Trump Biological Validation?
Many a successful investigator working at the interface between molecular biology, genetics and computation will recognize the imperative to obtain biological validation for computational...
Jul, 01, 2008
The Top Ten Advances of the Last Decade & The Top Ten Challenges of the Next Decade

A recognition of biocomputing's successes and a prediction of what's to come

The last ten years have seen huge leaps in biomedical computing. We now have new ways to integrate and understand vast quantities of data; the capacity for multi-scale biological modeling; and a...
bioinformatics tools, biomedical computing, CAD, computational modeling, data mining, disease surveillance, dynamic modeling, education, eric jakobsson, function prediction, genetic association, genome annotation, in silico screening, medical informatics, neuromodeling, prosthetics, sequence alignment, structure prediction, systems biology, systems biomedicine, telemedicine, tomography
Jun, 01, 2005
Simulating Cells in Context: Bringing Mechanics Into Play
Like humans, cells are affected by their physical environment, their neighbors, the context in which they exist. Much research has focused on the chemical signals that control cell behavior. But...
developmental biology
Sep, 01, 2011
Hot Bodies a Lure for Unseen Specks

Computing airflow dynamics

We can’t see them, but tiny particles—dust, pollen, microbes, and the like—swirl around us in complicated, turbulent pathways. New numerical simulations suggest that, at least in...
Jun, 01, 2010
VIEW THIS ISSUE IN PDF
Feb, 22, 2012
Decoding Promotion
Despite their identical genomes, cells in the body develop distinct personalities—become neurons or liver cells, for instance—due to differences in gene expression. The mechanism that...
Apr, 01, 2009
Profiles in Computer Science Courage Part I: Reflections on the rewards of plunging into biomedicine

Interviews with Leonidas Guibas, Ron Shamir, Michael Black, David Haussler, Daphne Koller, Erin Halperin, Gene Myers, Paul Groth and Bruce Donald

To a computer scientist, the fields of biology and medicine can seem like the vast Pacific Ocean, says Leonidas Guibas, PhD, professor of computer science at Stanford University. “You go to the...
Careers, computer science
Apr, 01, 2011
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