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Editor's Picks Fall 2005

Open Source reflections; designing with code re-use; and Cygwin

Do you have a few favorite books that you recommend to anyone with an interest in biomedical computing? Are there software products or Web sites that you love to evangelize? We’d like to open...
Sep, 01, 2005
Cooking Cancer With Gold Nanoshells

Computationally modeling the hot spots

Tiny gold particles that absorb laser light and convert it into heat are a promising therapy for destroying tumors. However, controlling the temperature of such gold nanoshells is crucial: The shells...
Jan, 01, 2010
Modeling Sperm: The Finer Points of Fertilization

Navigating the oviduct and other mysteries

The essential elements of human fertilization are clear: sperm swim through the uterus, travel up the fallopian tube, and fertilize an egg. Not as well understood are the the nitty-gritty details of...
agent-based models, fertilization, sperm
Jun, 19, 2013
Assembling The Aging Puzzle: Computation Helps Connect the Pieces

The complexity and variability of aging itself, along with the fragmented nature of researchers’ current understanding of aging, call for tools that can help scientists dig through mounds of data to find often subtle connections.

Jeanne Louise Calment of Arles, France rode a bicycle until she was 100 years old. When she gave up smoking at age 117, her doctor suspected it was out of pride. (She couldn’t see well enough...
Apr, 01, 2008
Profiles in Computer Science Courage Part I: Reflections on the rewards of plunging into biomedicine

Interviews with Leonidas Guibas, Ron Shamir, Michael Black, David Haussler, Daphne Koller, Erin Halperin, Gene Myers, Paul Groth and Bruce Donald

To a computer scientist, the fields of biology and medicine can seem like the vast Pacific Ocean, says Leonidas Guibas, PhD, professor of computer science at Stanford University. “You go to the...
Careers, computer science
Apr, 01, 2011
Behind the Connectome Commotion

Exploring the current state of connectomics--in the midst of hype

Connectomics is having a moment. Following on the heels of genomics, proteomics, transcriptomics, metabolomics, and microbiomics, the latest “omic” to seize the spotlight is generating...
brain, connectome
Jun, 20, 2013
Point/Counterpoint: Clinical Data Repositories: Less than meets the eye OR More valuable than you'd expect?
POINT/ Less than meets the eye                                             ...
Oct, 05, 2012
Visualizing Markov State Models Using MSMExplorer

A new application automates MSM visualization

An unfolded protein can move through thousands of intermediate structures (conformations) before finding its properly folded state. One approach to understanding this process involves simulating a...
Feb, 19, 2013
Matters of Time: Tick Tock Go the Simulations

Computing using time steps -- a necessary approximation

Time flows like a continuous, steady river. And it moves forward—never back. These facts create inherent challenges for computer simulations of biological molecules in motion.   It would...
molecular dynamics, timesteps
Jun, 19, 2013
Tapping the Brain: Decoding fMRI

How researchers are predicting specific thoughts from brain activity

Revealing the brain’s hidden stash of pictures, thoughts, and plans has, until recently, been the work of parlor magicians. Yet within the last decade, neuroscientists have gained powerful...
fMRI, memories, multivoxel pattern analysis, MVPA, neuroscience
Jan, 02, 2012
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